Simethicone is an anti-flatulence agent used to relieve pressure, bloating, and symptoms referred to as gas. Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination.
- Mechanism
- Curator reviewed · 1 reference
Simethicone is a surfactant that decreases the surface tension of gas bubbles in the gastrointestinal tract, more easily allowing gas to exit the body.
- Primary indication
- Simethicone is indicated for the treatment of bloating, pressure, and cramps caused by gas.Curator reviewed · 46 structured indications
- Formula / weight
- C6H18O4Si3 · 238.461 g/mol (avg)
- First approval
- Canada, 1997
- Also known as
- Simeticone
- Brand names
Resolves to
Compound
Clinical / RWD
Structure
InChIKey
AMTWCFIAVKBGOD-UHFFFAOYSA-NSMILESO=[Si]=O.CO[Si](C)(C)O[Si](C)(C)CTargets
What you can answer from here — as of May 03, 2025
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Simethicone, and which of those have an active Phase 3 trial?
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